• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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    • 专利摘要:
    12 ABSTRACT A method and a device for improving sustained functionality and measurementaccuracy in a urine handling system having inner surfaces coming into contactwith urine, the method comprising the following steps: - applying an oil mixture to the inner surfaces of the urine measurement systemby providing a water-soluble capsule in the urine handling system upstream of ameasurement portion and a siphoning portion of a urine measurement chamber of the system.
    公开号:SE1350318A1
    申请号:SE1350318
    申请日:2013-03-15
    公开日:2014-09-16
    发明作者:Mikael Charlez；Mikael Löfgren
    申请人:Observe Medical Aps；
    IPC主号:
    专利说明:

    1 IMPROVED URINE MEASUREMENT DEVICE AND METHOD Technical FieldThe present invention relates to a device and a method for electronic measurementof urine production of a patient wearing a catheter. More specifically it relates to devices and methods for increasing operational time and accuracy of such a device.
    Background Art Electronic urine measurement systems are known in the art.
    WO 2010/149708 A1 discloses a urine measurement device for measuring urineproduction of a patient having a urine catheter. The device uses capacitive measurementsfrom electrodes arranged close to a self emptying measurement chamber to calculate theurine level in the measurement chamber.
    US3919455 describes a device comprising a siphon chamber for the urine with aself emptying function, and wherein the urine volume is measured with the aid of an opticand/or electric sensor. When the urine level in the siphon chamber increases, thecapacitance between two electrodes in the walls of the siphon chamber changes. ln this waya signal is created that corresponds to the amount of urine in the siphon chamber. See e.g.figure 4 and column 4 lines 34 to 52.
    US20110146680A1 discloses a method for manufacturing a silicone catheterwherein the catheter is immersed in oil before it is immersed in a liquid comprising theantimicrobial substance chlorhexidine gluconate in order to make the chlorhexidine gluconate better adhere to the catheter.
    Summary of the lnvention Urine meter systems in general are depending on a connection to a urine catheter inorder to get access to the urine-bladder and drain urine from the bladder through a tubingsystem. The urine is led through a measuring unit and then collected in a collection bag.
    Urinary Tract Infection (UTl) is the most common nosocomial infection within thehealthcare system today. The UTl extends length of stay, increase costs and contributes toan additional risk to the patients' health status. lt's usually related to the installation of saidurine catheter. lt's revealed through clinical research that the risk of UTl increases by 10%each day the catheter stays in the urinary tract. Bacteria has either their entrance from theoutside of the body (64%) or from the very inside (36%). 2 The inventors have realised, with the aid of literature studies that in in-vitro systembacterial colonisation generates a bio film that becomes mineralised (encrustation). ln sterileurine, the development of encrustation has been shown to be dependent on urinaryproperties such as pH and ionic strength as well as on the biomaterial hydrophobicproperties. Urine is generally free from bacteria and thus it is the chemistry of the urine in ameasuring and/or collecting environment that dominates the variables. ln infected urine,enzyme urease produced by adhered bacteria hydrolyses the urea to produce ammonia.This elevates the urine pH, a condition that favours the precipitation of magnesium andca|cium in the form of struvite and hydroxyapatite (HA). These minerals are two major component of encrustation.
    Said bio-film and related risk of nosocomial UTls are not visible to the human naked eye, at least not in the early stages of formation.
    Sensor arrangement, signal processing, and signal interpretation methods of signalscoming from a capacitive sensor system of a urine measurement system for measuring theurine production of a patient having a urine catheter, may all suffer from harder measuringconditions that are likely to arise over time during prolonged use of such a measuringsystem.
    The inventors have presented the idea that surface degeneration may impairfunction of a capacitive measuring system and may cause a dysfunction of the siphon portionof the self-emptying chamber. They have conducted experiments around how the presenceof a purpose selected oil in the measurement chamber of the siphon system prolongsoperational life the same. They have also suggested that priming of luminal surfaces of the system may be achieved by self-priming with the aid of the urine flowing through the system.
    The present invention is providing a device and a method for improving the abovementioned inconveniences by the step(s) of applying a low viscosity oil to the inner surfacesof a urine handling system, with the purpose of arriving at a urine handling system withsustained functional reliability and sustained measurement accuracy, in particular duringprolonged use. The effect may be due to the oil influencing factors affecting bacterial growthand bio-film formation. The effect may also come from other mechanisms or from asynergetic effect not yet fully understood.
    The present invention discloses a urine handling system of a measurement typehaving a capacitive sensor system working together with a self emptying measurementchamber and being provided with a capsule of a material that will disintegrate when coming into contact with urine, e.g. a water soluble material. The capsule is initially filled with a 3 purpose selected oil and when the capsule disintegrates the oil is transported with the aid ofthe urine flow to become applied to those surfaces of the urine handling system that becomes exposed to urine.
    The invention is particularly useful in systems that use electronic methods for measuring theamount of urine passing through the system, for example capacitive measurement methods.lt will also provide an advantage in systems using self emptying chamber(s) to handle urinemeasurements. Tests have shown that the self emptying function of such chambers willcontinue to function reliably for several days, while within a system without the solution of the present invention, functionality may be compromised as soon as after 24 hours.
    A urine measurement system according to the present invention thus comprises awell defined measurement chamber for temporarily collecting an amount of urine to measure.The chamber may be of a self emptying siphoning type, that is, the chamber, when it becomes full, empties itself by means of siphoning technique.
    Thus, according to a first aspect of the present invention there is provided a urinehandling system capsule for releasing an oil mixture in the lumen of a urine handling system,the capsule comprises a capsule wall defining a space filled with an oil mixture, wherein theoil mixture comprises 90-100% of an oil selected from the group consisting of silicone fluidsand mineral oils or a mixture thereof, and having a viscosity in the interval of 300 to 400 cSt,and wherein the capsule wall is made of a water-soluble material.
    The capsule wherein the water-soluble material is selected from the groupconsisting of gelatine and hydroxypropyl methylcellulose or a mixture thereof.
    The capsule wherein the oil composition is selected from the group of silicone fluids.
    The capsule wherein the oil composition is selected from the group of linearpolydimethylsiloxanes.
    The capsule wherein the viscosity of the oil is in the interval of 345 to 355 cSt.
    The capsule wherein the viscosity of the oil is 350 cSt.
    According to a second aspect of the present invention there is provided a urinemeasurement system comprising a urine measurement chamber and an electronicmeasurement system comprising electrodes arranged outside but close to saidmeasurement chamber, measure changing capacitance values as urine level inside thechamber increases, wherein the capsule mentioned above is arranged in the luminal space of the measurement system. 4 The urine measurement system, wherein the capsule is arranged upstream of themeasurement chamber or in an upstream portion of the measurement chamber. The urinemeasurement system, wherein the capsule and possible parts of the capsule wall in earlystages of disintegration is prevented from entering a measurement portion of themeasurement chamber by a grate.
    The urine measurement system wherein the grate is made of a metal or polymermaterial.
    The urine measurement system, wherein the material of the measurement chamberis selected from a group consisting of polymer materials.
    The urine measurement system, wherein the material of the measurement chamberis selected from a group consisting of glass materials.
    The urine measurement system, wherein the material of the measurement chamber is selected from a group of materials having lipophilic properties.
    According to a third aspect of the present invention there is provided a method forimproving sustained functionality and measurement accuracy in a urine measurementsystem having inner surfaces coming into contact with urine, the method comprising thefollowing steps: - applying an oil mixture to the inner surfaces of the urine measurement system.
    The method wherein the oil mixture comprises 90-100% of an oil selected from agroup consisting of silicone fluids, and mineral oils, or from a mixture thereof.
    The method wherein the oil mixture is applied by connecting a patients urinarycatheter with the urine measurement system mentioned above provided with the capsule mentioned above.
    According to a fourth aspect of the present invention there is provided a use of acompound X in the application Y, wherein the compound X is an oil mixture comprising 90-100% of an oil selected from the group consisting of silicone fluids and mineral oils or amixture thereof, and having a viscosity in the interval of 200 to 600 cSt, and wherein theapplication Y is treatment of luminal surfaces of a urine handling system.
    The use of above, wherein the viscosity is in the interval of 300 to 400 cSt, or 345 to355 cSt.
    The use, wherein the compound X is an oil mixture void of antimicrobial agent.
    Brief Description of the Drawings 5 The invention will now be further explained with the aid of one or more embodiments of the invention in conjunction with the accompanying drawings of which: Figure 1a is a front view of a measurement chamber of a urine handling system.Figure 1b is view of the measurement chamber of figure 1a wherein a front wall isremoved exposing the inner structure including capsule/oil pill arrangement and grate arrangement.
    Detailed description Definitions ln the context of the present invention the following terms and phrases will be used havingthe following meanings: A “urine handling system” denotes a system for handling of urine emanating from a humanpatient involved in a care situation, including but not limited to, a nursing situation and atreatment situation.
    A “urine measurement system” denotes a system designed to measure the amount of urineemanating from a human patient involved in a care situation, including but not limited to, anursing situation and a treatment situation.
    The term "silicone oil" is intended to include silicone esters or other liquid siliconecompounds with the general formula: Ro sta-Not w sin Ä- t- t_ _ V:R æ Ä _» . 3_ . _ Where each R can be an aliphatic group such as an alkyl group, for example a methyl, ethylor propyl radical or alkoxy group or a phenyl group, or combinations thereof; and where x has a value of from about 0 to about 10,000, preferably from about 1 to about 200,and most preferably from about 10 to about 125.
    The problemUrine is a body liquid that may be very aggressive on manmade surfaces, in particular on surfaces inside a urine measurement system. The urine measurement systemaccording to the invention may be a closed system that comprises a tubing systemconnected to a patient's catheter, a measurement chamber and a collection bag. The tubing system leads the urine from the urine bladder to the measurement chamber where a 6 capacitive, contact-less sensor system senses the signals through the wall of themeasurement chamber, and thereof calculates the volume. The chamber wall is preferably ofa rigid polymeric material, easily obtained in medical equipment grades. The urine ispreferably collected in a collection bag after it has been measured. Such a collection bag ispreferably made of a flexible polymeric material, and has a volume considerably larger thanthe volume of the measurement chamber.
    The measurement chamber is preferably devised to self-empty at a certain volumearound 15-20ml. The challenge in said self-emptying measurement chamber is to handle theeffects of degenerative process compromising the electric and physical properties of thedelicate surfaces of the measurement chamber caused by the urine over time.
    Thus, and as also mentioned above, the inventor has realised, and also experience,that within an unforeseeable amount of time there is a decrease of signal through themeasurement chamber wall that seems to be caused by a bio film formation on thesurface(s) corresponding to where the sensors are arranged. There seems to be aconsiderable risk of a degeneration of the delicate surfaces within the region of the self-emptying system which may lead to a dysfunction of the self-emptying mechanism.
    One solution to the problem would be to replace the chamber when signs ofdysfunction are noticeable. However, it would be an advantage if this could be avoided, since it requires more resources.
    The solution Now turning to figures 1a and 1b, the present invention teaches to apply asubstance to the surfaces of the urine measurement system to improve sustainedmeasurement functionality and accuracy. lf a urine measurement system provided with a measurement chamber 101comprising a siphoning self-emptying arrangement begins to execute premature emptyingsequences, it is likely that surface(s) of the measurement chamber 101 critical to initiation ofthe self-emptying sequence, has become compromised. The solution involves arranging anoil releasing device 105 early in the flow path of the urine measurement system, and to letsaid oil releasing device 105 release oil into the system for adhering to the luminal surfacesof the system. Subsequent to release the urine, as being a watery, oil repellant fluid, aids indispersing the oil, which oil gets on top of the urine, and during a filling phase of themeasurement chamber, takes with it the oil, which oil adheres to the luminal surfaces in need thereof. 7 lt is realised by the skilled reader that this measure of providing an oil releasingdevice would improve not only a urine measurement system, but any urine handling system liable or susceptible to degradation over time.
    Capsule The oil releasing device is preferably implemented as a capsule 105 made of awater-soluble material. The capsule encapsulates an amount of oil. The capsule is preferablyof a shape selected from the group of cylindrical, cylindrical with hemispherical ends,spherical, oval, elliptical or of a shape rounded cubic or tablet, or of any shape suitable to thepurpose.
    The material of the capsule is a water-soluble material, preferably one thatdisintegrates in a few minutes when exposed to urine flow. One possible material of thecapsule is polyvinyl alcohol (PVOH). Most preferred, however, is a material selected from thegroup of gelatine or hyfdroxypropyl inethyleellulose, such as for example the :naterial ofLECAPS capsuies from CAPSUGEL ~ www.capsugel.com. One particular advantage ofPVOi-l is a very quick release of the oli because of fast disintegratton. One advantage ofgelatine or hydroxypropyl ntethyloeilulose is easy sterltization of the capsule.
    To prevent the capsule from interferirig with urine ftovtf in the measurement chamberit attvantageotis to provide a grate 't 10 or similar arrangement to prevent early, non dissoivedfragments of the capsule to ciog the ftow of urine. lt is also advantages to provide such agrate to oonfine the oapsute during transport and pre-rise to an tippar portion of theineastlrentent chamber.
    Titus, the grate 110 is arranged to prevent pieces of non-dissolved capsule fromtravelling with the urine flow and temporarily blocking possible valves or siphoning system.The term “measurement chamber” may be used as a general term denoting the wholechamber comprising a first portion 115, i.e., an inlet upstream portion or ”atrium”, a secondportion 120 midstream which is the actual measurement portion of the measurementchamber presenting important surfaces for the sensors. Further downstream is provided athird portion 130, 140 providing the self-emptying siphoning arrangement 130 and outletpiping 140. To be able to treat the surfaces of the second portion 120 and the third portion130 with oil from the capsule, the capsule is provided in the first portion 115, the atrium. Thegrate 110 is arranged between the atrium 115 and the second portion 120 of the measurement chamber 101. üThe oil is a purpose selected oil. Viscosity may be in the interval of 200 to 600 centiStoke (cSt, mm2/s). Viscosity is preferably in the interval of 300 to 400 centiStoke (cSt, mmz/s) and 8 of a grade approved for medical use. lt is preferably an oil comprising as a major constituentan oil preferably selected from the group of silicone fluids or mineral oils or from acombination thereof.
    The silicon oil is preferably selected from polydimethylsiloxane, polymethylphenylsiloxane,polydipropylsiloxane, and polyphenylsiloxane. More preferably polydimethylsiloxane.
    Most preferred is an oil composition selected from the group of linear polydimethylsiloxanes,such as for example SILBIONE oil 70047 V 350 from Bluestar Silicones -wwvv.blustarsilicones.com. Most preferred is an oil comprising 90-100% silicone oil ofviscosity about 350 cSt. The oil may be free of additive, or may comprise one or moreadditives.
    The volume of oil provided in the capsule to achieve the described has been tested and effect is achieved with a volume of 0.5 ml of oil.
    Oil treatment without capsule The inventors have also generalised that the purpose selected oil disclosed abovemay be applied to urine handling system surfaces using other methods than by capsule anddistribution with the aid of urine flow. Thus a specific use of the oil is made an object of thepresent invention;lt is disclosed the use of a compound X in the application Y, wherein the compound X is anoil mixture comprising 90-100% of an oil selected from the group consisting of silicone fluidsand mineral oils or a mixture thereof, and having a viscosity in the interval of 200 to 600 cSt,preferably within the interval of 300 to 400 cSt, more preferred 345 to 355 cSt, and mostpreferred 350 cSt, and wherein the application Y is the treatment of luminal surfaces of aurine handling system or a urine measurement system. With the term "treatment" is heremeant an activity wherein the oil is applied to the surface in question regardless of themethod of application. Preferred methods include pouring oil into the luminal space,spraying, painting, immersion, soaking, releasing, and distribution with the aid of a Wateryfluid. The Watery fluid may be urine. ln the present invention the oil treatment as described is taught as single step oftreatment of the surfaces for increased operational time. The oil is a non-complex compoundinvolving no other substance, like an antimicrobial agent, such as for example chlorhexidine.lt is an advantage that no other substance, like an antimicrobial agent, such as for examplechlorhexidine, is needed. The oil mixture may advantageously be void of such antimicrobial substance. This is also true regarding the oil mixture when released by capsule.
    Material of measurement chamber 9 The material of the measurement chamber is preferably a polymer of medicalequipment grade. More preferred a polymer of medical equipment grade, wherein thepolymer exhibits a lipophilic surface. Most preferred is polypropylene. Tests have shown thatlipophilic material keep the oil at the chamber surface, in contrast to a lipophobic material which will repel the oil, and the oil would be washed away by the urine rather quickly by time.
    Advantagesln addition to improved measurement accuracy and operational life of the measurement chamber, the capsule allows that the oil, as an active ingredient, is inactiveduring shelf life and activated first in the clinical setting.Further, the capacitive sensors are not influenced, or being influenced only negligible by the oil mixture.
    EXAMPLES/TESTSThe following table illustrates some combinations of capsule material, oil, and measurement chamber material.
    EXAMPLE Capsule Oil/viscosity Chamber Prolongedmaterial material operationaltime (%)EX 1 (*) gelatine Silicone/ 350 cSt polymer 50 to 5600 ln a series of tests it has been found that in a system without oil a goodmeasurement signal will remain for approximately 6 to 36 hours, while in a similar system provided with oil, the measurement signal remain good for 2 to 14 days, i.e., 48 to 336 hours.
    权利要求:
    Claims (18)
    [1] 1. A urine handling system Capsule (105) for releasing an oil mixture in the lumenof a urine handling system, the capsule (105) comprising a capsule wall defininga space filled with an oil mixture, wherein the oil mixture comprises 90-100% ofan oil selected from the group consisting of silicone fluids and mineral oils or amixture thereof, and having a viscosity in the interval of 300 to 400 cSt, and wherein the capsule wall is made of a water-soluble material. The capsule (105) according to claim 1 wherein the water-soluble material isselected from the group consisting of geiatine, hydroxyiaropyl rnethyiceliuiose, and polyvinyl alcohol (PVOH) or a :nixture thereof. The capsule (105) according to claim 1 or 2 wherein the oil composition is selected from the group of silicone fluids. The capsule according to claim 3 wherein the oil composition is selected from the group of linear polydimethylsiloxanes. The capsule according to claim 1, 2 or 3 wherein the viscosity of the oil is in theinterval of 345 to 355 cSt. The capsule according to claim 4 wherein the viscosity of the oil is 350 cSt. A urine measurement system (101) comprising a urine measurement chamber(101) and an electronic measurement system comprising electrodes arrangedoutside said measurement chamber (101) to measure changing capacitancevalues as urine level inside the chamber (101) increases, wherein a capsule(105) according to any of claims 1 to 6 is arranged in the luminal space of the measurement system. The urine measurement system according to claim 7, wherein the capsule (105)is arranged upstream of the measurement chamber or in an upstream portion ofthe measurement chamber (101) and is prevented from entering the measurement chamber by a grate (110). The urine measurement system according to claim 7 wherein the grate (110) is made of a metal or polymer material. 10. 11. 12. 13. 14. 15. 16. 17. 18. 11 The urine measurement system according to claim 7, wherein the material of the measurement chamber is selected from a group consisting of polymer materials. The urine measurement system according to claim 7, wherein the material of the measurement chamber is selected from a group consisting of glass materials. The urine measurement system according to claim 7, wherein the material of themeasurement chamber is selected from a group of materials having lipophilic properties. A method for improving sustained functionality and measurement accuracy in aurine measurement system having inner surfaces coming into contact with urine,the method comprising the following step(s): - applying an oil mixture to the inner surfaces of the urine measurement system. The method according to claim 13 wherein the oil mixture comprises 90-100% ofan oil selected from a group consisting of silicone fluids, and mineral oils, or from a mixture thereof. The method according to claim 13 or 14 wherein the oil mixture is applied byconnecting a patients urinary catheter with the urine measurement system of any of claims 7 to 12 provided with the capsule of any of claims 1 to 6. Use of a compound X in the application Y, wherein the compound X is an oilmixture comprising 90-100% of an oil selected from the group consisting ofsilicone fluids and mineral oils or a mixture thereof, and having a viscosity in theinterval of 200 to 600 cSt, and wherein the application Y is treatment of luminal surfaces of a urine handling system. The use according to claim 16, wherein the viscosity is in the interval of 300 to400 cSt, or 345 to 355 cSt The use according to claim 16 or 17, wherein the compound X is an oil mixture void of antimicrobial agent.
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    同族专利:
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    SE537614C2|2015-08-04|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    SE1350318A|SE537614C2|2013-03-15|2013-03-15|Improved urine measuring device and procedure|SE1350318A| SE537614C2|2013-03-15|2013-03-15|Improved urine measuring device and procedure|
    RU2015144023A| RU2665029C2|2013-03-15|2014-03-14|Improved urine measurement device and method|
    ES14711214.8T| ES2626973T3|2013-03-15|2014-03-14|Improved urine measurement device and method|
    US14/776,776| US9931070B2|2013-03-15|2014-03-14|Urine measurement device and method|
    CN201480015096.7A| CN105120752B|2013-03-15|2014-03-14|Improved urine measurement apparatus and method|
    JP2015562241A| JP6416796B2|2013-03-15|2014-03-14|Apparatus and method for improved urine measurement|
    PCT/EP2014/055189| WO2014140328A1|2013-03-15|2014-03-14|Improved urine measurement device and method|
    EP14711214.8A| EP2967464B1|2013-03-15|2014-03-14|Improved urine measurement device and method|
    BR112015022693A| BR112015022693A2|2013-03-15|2014-03-14|urine measurement system, method for inhibiting functionality and accuracy measurement failures, and use of capsule to release oil mixture in light surface treatment|
    US15/908,918| US10188339B2|2013-03-15|2018-03-01|Urine measurement device and method|
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